PTH(1-34) Treatment As A Novel Method For Increasing Turnover Of Bound Bisphosphonates In Fracture Repair
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منابع مشابه
Management of glucocorticoids-induced osteoporosis: role of teriparatide
Glucocorticoids (GC)-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, which leads to an increased fracture risk in patients. The normal bone turnover depends on a balance between osteoblasts and osteoclasts activity and GC can cause a rapid bone loss, decreasing bone formation and increasing bone resorption. The decreased bone formation is mainly due to the GC-ind...
متن کاملTriweekly administration of parathyroid hormone (1–34) accelerates bone healing in a rat refractory fracture model
BACKGROUND Some reports have shown that intermittent parathyroid hormone (PTH) (1-34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic intermittent administration of PTH (1-34) has a beneficial effect on bone healing in a rat refractory fracture model. METHODS We created a refractory femoral fracture model in...
متن کاملCombination and sequential therapy with PTH and bisphosphonates.
with anti-resorptive agents, such as bisphosphonates, offer the potential for synergistic benefits for patients at high risk of fracture. Although fracture endpoint studies exist for monotherapy with either bisphosphonates or PTH, such studies do not exist for treatment strategies involving combined or sequential use of PTH and bisphosphonates, and only studies with surrogate endpoints currentl...
متن کاملEconomic Analysis of Bisphosphonate Use after Distal Radius Fracture for Prevention of Hip Fracture
Background: Osteoporosis is a common condition among the elderly population, and is associated with an increased risk of fracture. One of the most common fragility fractures involve the distal radius, and are associated with risk of subsequent fragility fracture. Early treatment with bisphosphonates has been suggested to decrease the population hip fracture burden. However, there have been no p...
متن کاملPARATHYROID HORMONE AND TERIPARATIDE FOR THE TREATMENT OF OSTEOPOROSIS: A REVIEW OF THE EVIDENCE AND SUGGESTED GUIDELINES FOR ITS USE. Corresponding Author
All therapies currently recommended for the management of osteoporosis act mainly to inhibit bone resorption and reduce bone remodeling. Parathyroid hormone and its analog, teriparatide (recombinant human PTH(1-34), represent a new class of anabolic therapies for the treatment of severe osteoporosis, having the potential to improve skeletal micro-architecture. Significant reductions in both ver...
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